Explore/LL-37: A Multifaceted Host Defense Peptide

LL-37: A Multifaceted Host Defense Peptide

Muscle / Recovery • Peptide

◐ Emerging EvidenceResearch Only
Evidence
Good6/10
Hype
Moderate5/10
Risk
Moderate4/10
Beginner Friendly
Good6/10

Plain English Summary

LL-37 is a human cathelicidin peptide that plays a crucial role in innate immunity by transporting cGAMP to activate STING signaling, enhancing antiviral immunity, and exhibiting antimicrobial activity. It is influenced by vitamin D and can also induce cytotoxic effects in certain cell types.

What People Use It For

Enhance immune responseAntimicrobial activityImmune modulation

Side Effects & Risks

Common Side Effects

Cytotoxicity to host cells (e.g., osteoblast-like cells)Potential inflammatory responses

References

  • 1https://pubmed.ncbi.nlm.nih.gov/35649354/
  • 2https://pubmed.ncbi.nlm.nih.gov/38642493/
  • 3https://pubmed.ncbi.nlm.nih.gov/35954305/
  • 4https://pubmed.ncbi.nlm.nih.gov/39170953/
  • 5https://pubmed.ncbi.nlm.nih.gov/36769137/
  • 6https://pubmed.ncbi.nlm.nih.gov/36763254/
  • 7https://pubmed.ncbi.nlm.nih.gov/36781570/
  • 8https://pubmed.ncbi.nlm.nih.gov/36294968/

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Educational Content Only

This is not medical advice. Always consult a licensed healthcare provider before using any compound. No dosing or sourcing guidance is provided.