Explore/MOTS-c

MOTS-c

Longevity • Peptide • Peptide

Also known as: Mitochondrial ORF of the 12S rRNA type-c

○ Early ResearchResearch Only
Evidence
Moderate4/10
Hype
High7/10
Risk
Low3/10
Beginner Friendly
Moderate4/10

Plain English Summary

A mitochondria-derived peptide encoded in mitochondrial DNA that regulates metabolic homeostasis. Associated with longevity, insulin sensitivity, and exercise mimicry — sometimes called an 'exercise in a shot.'

What People Use It For

LongevityMetabolic healthInsulin sensitivityExercise performanceAnti-aging

Realistic Expectations

Best Case

Improved metabolic flexibility, insulin sensitivity, and energy levels.

Common Outcome

Subjective improvements in energy and recovery; objective metabolic changes unverified.

Low / No Response

No measurable effect; human data insufficient to predict response.

Side Effects & Risks

Common Side Effects

Injection site reactionsFatigue initiallyLimited human safety data

Warnings

  • Almost all evidence from animal studies; human research is very early stage
  • No regulatory approval anywhere
  • Long-term human effects unknown

Who This Is Not For

Anyone outside of supervised research settings. Not established for general consumer use.

Commonly Confused With

EpitalonHumanin

Timeline of Expected Changes

No established human timeline; animal studies suggest weeks of consistent use.

Researcher Sentiment

No votes yet — be the first

Educational Content Only

This is not medical advice. Always consult a licensed healthcare provider before using any compound. No dosing or sourcing guidance is provided.