Explore/p21 (WAF1/Cip1)

p21 (WAF1/Cip1)

Longevity • Peptide

○ Early ResearchResearch Only
Evidence
Weak2/10
Hype
Moderate5/10
Risk
High8/10
Beginner Friendly
Weak1/10

Plain English Summary

p21 is a cyclin-dependent kinase inhibitor that acts as a fundamental biological regulator. It is best known for its role in halting the cell cycle in response to DNA damage and regulating cellular senescence (the state where cells stop dividing but remain metabolically active).

What People Use It For

Cellular senescence researchOncology studiesDNA damage response analysisImmunosurveillance investigation

Side Effects & Risks

Common Side Effects

Potential for premature cell deathDysregulation of normal cell cycle progressionRisk of oncogenic signaling in specific contextsImmune system hyper-activation

References

  • 1https://pubmed.ncbi.nlm.nih.gov/27156098/
  • 2https://pubmed.ncbi.nlm.nih.gov/34709885/
  • 3https://pubmed.ncbi.nlm.nih.gov/35024619/
  • 4https://pubmed.ncbi.nlm.nih.gov/31416295/
  • 5https://pubmed.ncbi.nlm.nih.gov/35443176/
  • 6https://pubmed.ncbi.nlm.nih.gov/41178462/
  • 7https://pubmed.ncbi.nlm.nih.gov/31083332/
  • 8https://pubmed.ncbi.nlm.nih.gov/32481484/

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Educational Content Only

This is not medical advice. Always consult a licensed healthcare provider before using any compound. No dosing or sourcing guidance is provided.