Explore/Rapamycin (Sirolimus)

Rapamycin (Sirolimus)

Longevity • Research Compound

◐ Emerging EvidencePrescription Drug
Evidence
Weak3/10
Hype
High9/10
Risk
High8/10
Beginner Friendly
Weak2/10

Plain English Summary

Rapamycin is an FDA-approved immunosuppressant medication used primarily in organ transplantation. In the context of longevity research, it is studied for its ability to inhibit the mTOR pathway, a key regulator of cell growth and metabolism, which has shown significant life-extending effects in various animal models.

What People Use It For

Extended healthspanCellular autophagy inductionAnti-cancer preventionMetabolic optimization

Side Effects & Risks

Common Side Effects

Immune system suppressionIncreased risk of infectionMouth ulcers (stomatitis)HyperlipidemiaHyperglycemiaPotential impaired wound healing

References

  • 1https://pubmed.ncbi.nlm.nih.gov/37191826/
  • 2https://pubmed.ncbi.nlm.nih.gov/39498504/
  • 3https://pubmed.ncbi.nlm.nih.gov/37057884/
  • 4https://pubmed.ncbi.nlm.nih.gov/30854544/
  • 5https://pubmed.ncbi.nlm.nih.gov/36617414/
  • 6https://pubmed.ncbi.nlm.nih.gov/30870215/
  • 7https://pubmed.ncbi.nlm.nih.gov/40704394/
  • 8https://pubmed.ncbi.nlm.nih.gov/38839644/

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Educational Content Only

This is not medical advice. Always consult a licensed healthcare provider before using any compound. No dosing or sourcing guidance is provided.