Plain English Summary
Klotho is an anti-aging protein primarily produced in the kidneys. It exists as a membrane-bound receptor and a circulating soluble hormone (s-Klotho). It acts as an obligate co-receptor for FGF23 to regulate phosphate and vitamin D metabolism and functions as a systemic pleiotropic factor that influences multiple signaling pathways related to inflammation, cellular senescence, and oxidative stress.
What People Use It For
Side Effects & Risks
Common Side Effects
References
- 1https://pubmed.ncbi.nlm.nih.gov/39272986/
- 2https://pubmed.ncbi.nlm.nih.gov/35903083/
- 3https://pubmed.ncbi.nlm.nih.gov/19730882/
- 4https://pubmed.ncbi.nlm.nih.gov/16123266/
- 5https://pubmed.ncbi.nlm.nih.gov/38164143/
- 6https://pubmed.ncbi.nlm.nih.gov/21346722/
- 7https://pubmed.ncbi.nlm.nih.gov/26746857/
- 8https://pubmed.ncbi.nlm.nih.gov/32297880/
Researchers also explore
Epithalon (Ala-Glu-Asp-Gly)
Epithalon is a synthetic tetrapeptide synthesized from a sequence derived from the bovine pineal gland extract, known for its potential geroprotective and neuroendocrine effects. It has been studied for its antioxidant and neuroprotective properties, as well as its influence on melatonin synthesis and cellular health. Research suggests that Epithalon may enhance longevity and suppress tumor development in animal models, making it an intriguing candidate in aging and cancer research.
SS-31 (Elamipretide)
SS-31, also known as Elamipretide, is a synthetic peptide designed to target mitochondria. It acts as an antioxidant that stabilizes the inner mitochondrial membrane, helping to protect cells from oxidative stress, improve energy production, and reduce cell death in conditions involving mitochondrial dysfunction.
SS-31 (Elamipretide)
SS-31, also known as Elamipretide, is a synthetic tetrapeptide designed to target and protect mitochondria. By stabilizing the inner mitochondrial membrane and interacting with cardiolipin, it helps maintain mitochondrial energy production and reduce the generation of damaging reactive oxygen species (ROS) caused by stress or age-related dysfunction.
SS-31 (Elamipretide)
SS-31, also known as Elamipretide, is a mitochondria-targeted peptide designed to stabilize the inner mitochondrial membrane by binding to cardiolipin. It is primarily researched for its ability to reduce oxidative stress, improve mitochondrial bioenergetics, and protect against cellular damage in conditions involving ischemia, inflammation, and aging-related degeneration.
Researcher Sentiment
No votes yet — be the first
Educational Content Only
This is not medical advice. Always consult a licensed healthcare provider before using any compound. No dosing or sourcing guidance is provided.
