Explore/Klotho

Klotho

Longevity • Peptide

○ Early ResearchInvestigational
Evidence
Weak3/10
Hype
High8/10
Risk
Moderate4/10
Beginner Friendly
Weak2/10

Plain English Summary

Klotho is an anti-aging protein primarily produced in the kidneys. It exists as a membrane-bound receptor and a circulating soluble hormone (s-Klotho). It acts as an obligate co-receptor for FGF23 to regulate phosphate and vitamin D metabolism and functions as a systemic pleiotropic factor that influences multiple signaling pathways related to inflammation, cellular senescence, and oxidative stress.

What People Use It For

LongevityReduce inflammagingSupport kidney functionNeuroprotectionMuscle maintenance

Side Effects & Risks

Common Side Effects

Hypophosphatemia (if over-activity occurs)Potential interference with mineral homeostasisGeneral side effects remain poorly characterized in clinical trials

References

  • 1https://pubmed.ncbi.nlm.nih.gov/39272986/
  • 2https://pubmed.ncbi.nlm.nih.gov/35903083/
  • 3https://pubmed.ncbi.nlm.nih.gov/19730882/
  • 4https://pubmed.ncbi.nlm.nih.gov/16123266/
  • 5https://pubmed.ncbi.nlm.nih.gov/38164143/
  • 6https://pubmed.ncbi.nlm.nih.gov/21346722/
  • 7https://pubmed.ncbi.nlm.nih.gov/26746857/
  • 8https://pubmed.ncbi.nlm.nih.gov/32297880/

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Educational Content Only

This is not medical advice. Always consult a licensed healthcare provider before using any compound. No dosing or sourcing guidance is provided.