Longevity & Anti-Aging Compounds

SS-31, also known as Elamipretide, is a mitochondria-targeted peptide designed to stabilize the inner mitochondrial membrane by binding to cardiolipin. It is primarily researched for its ability to reduce oxidative stress, improve mitochondrial bioenergetics, and protect against cellular damage in conditions involving ischemia, inflammation, and aging-related degeneration.

SS-31, also known as Elamipretide, is a synthetic tetrapeptide designed to target and protect mitochondria. By stabilizing the inner mitochondrial membrane and interacting with cardiolipin, it helps maintain mitochondrial energy production and reduce the generation of damaging reactive oxygen species (ROS) caused by stress or age-related dysfunction.

A naturally occurring peptide derived from the thymus gland that plays a key role in immune regulation. FDA-approved in some countries for hepatitis and used off-label for immune support and cancer adjunct therapy.

SS-31, also known as Elamipretide, is a synthetic peptide designed to target mitochondria. It acts as an antioxidant that stabilizes the inner mitochondrial membrane, helping to protect cells from oxidative stress, improve energy production, and reduce cell death in conditions involving mitochondrial dysfunction.

NAD+ is a coenzyme found in every cell that's critical for energy metabolism and cellular repair. NAD+ levels naturally decline with age, which has made NAD+ supplementation (and precursors like NMN and NR) popular in the longevity space.

Epithalon is a tetrapeptide (Ala-Glu-Asp-Gly) derived from the pineal gland, known for its potential geroprotective and neuroendocrine effects. It may enhance melatonin synthesis and has been shown to have various biological and pharmacodynamic activities, including prolonging lifespan in animal models.

Epithalon is a synthetic tetrapeptide synthesized from a sequence derived from the bovine pineal gland extract, known for its potential geroprotective and neuroendocrine effects. It has been studied for its antioxidant and neuroprotective properties, as well as its influence on melatonin synthesis and cellular health. Research suggests that Epithalon may enhance longevity and suppress tumor development in animal models, making it an intriguing candidate in aging and cancer research.

SS-31 is a synthetic, mitochondrial-targeted peptide designed to stabilize the inner mitochondrial membrane by binding to cardiolipin. By protecting mitochondrial structure and integrity, it aims to enhance energy production (ATP) and mitigate oxidative stress in cells with high metabolic demand, such as those in the heart, kidneys, and eyes.

A mitochondria-derived peptide encoded in mitochondrial DNA that regulates metabolic homeostasis. Associated with longevity, insulin sensitivity, and exercise mimicry — sometimes called an 'exercise in a shot.'

Epithalon (Ala-Glu-Asp-Gly) is a therapeutic tetrapeptide known for its geroprotective and neuroendocrine properties, primarily linked to antioxidant effects and modulation of melatonin synthesis. It has shown potential in extending lifespan and reducing cancer incidence in animal studies, though human research is limited.

Epithalon, a synthetic tetrapeptide (Ala-Glu-Asp-Gly), has been studied for its potential geroprotective properties, including antioxidant effects, modulation of melatonin synthesis, and influence on lifespan extension in several animal models. Its mechanisms include enhancing telomerase activity and slowing the aging process, though further research is needed to validate these effects in humans.

Epithalon is a synthetic tetrapeptide known for its geroprotective properties, potentially enhancing longevity and neuroendocrine function. It has shown promise in preclinical models for prolonging lifespan and delaying age-related diseases, such as breast cancer.

Rapamycin is an FDA-approved immunosuppressant medication used primarily in organ transplantation. In the context of longevity research, it is studied for its ability to inhibit the mTOR pathway, a key regulator of cell growth and metabolism, which has shown significant life-extending effects in various animal models.

Thymalin is a polypeptide complex derived from the thymus gland, primarily recognized for its role in stimulating and modulating the immune system. Developed originally in Russia, it is studied for its potential geroprotective properties, which include improving immunological status, supporting metabolic homeostasis, and potentially increasing lifespan through the regulation of hematopoietic stem cell differentiation.

Klotho is an anti-aging protein primarily produced in the kidneys and brain. It functions as both a membrane-bound coreceptor for FGF23 and as a circulating hormone (s-Klotho) that regulates phosphate, calcium, and vitamin D metabolism. Research suggests that higher levels of Klotho are linked to extended lifespan and protection against various age-related degenerative diseases, whereas declining levels correlate with accelerated aging and chronic pathologies.

Epithalon is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from a component of pineal gland extracts, known for its potential geroprotective effects, including antioxidative and neuroprotective properties. It has been shown to influence melatonin synthesis and telomerase activity, suggesting a role in aging-related processes.

Klotho is an anti-aging protein primarily produced in the kidneys. It exists as a membrane-bound receptor and a circulating soluble hormone (s-Klotho). It acts as an obligate co-receptor for FGF23 to regulate phosphate and vitamin D metabolism and functions as a systemic pleiotropic factor that influences multiple signaling pathways related to inflammation, cellular senescence, and oxidative stress.

A synthetic tetrapeptide derived from the pineal gland hormone epithalamin. Researched primarily for its purported ability to lengthen telomeres and extend lifespan — though most evidence comes from animal studies.

Vilon is a synthetic dipeptide (Lysine-Glutamate) studied primarily in Eastern European research contexts as an 'anti-aging bioregulator.' It is believed to modulate gene expression and influence chromatin structure, potentially helping to reactivate genes that become silenced or condensed during the aging process.

P21 is a protein that acts as a critical regulator of the cell cycle, serving as a checkpoint to stop damaged or stressed cells from dividing. By inducing cell-cycle arrest, it helps prevent the replication of mutated DNA and aids in the clearance of senescent (aged/damaged) cells via the immune system.

p21 is a protein that plays a critical role in controlling cell growth and division. It acts as a gatekeeper, arresting the cell cycle to allow for DNA repair or to trigger immune surveillance when a cell is damaged or stressed. In the context of aging and cancer research, p21 is being studied as a marker for senescent (aged) cells and a potential therapeutic target for removing those cells to improve healthspan.

P21 is a protein that acts as a key regulator of the cell cycle, functioning as an inhibitor that stops cells from dividing when they are damaged or under stress. It plays a dual role in both suppressing tumors and facilitating DNA repair. In the context of longevity research, P21 expression is a marker for senescent cells, and research is ongoing into how modulating these cells might impact aging and physical function.

p21 is a cyclin-dependent kinase inhibitor that acts as a fundamental biological regulator. It is best known for its role in halting the cell cycle in response to DNA damage and regulating cellular senescence (the state where cells stop dividing but remain metabolically active).

Humanin is a mitochondria-derived peptide (MDP) that acts as a signaling molecule, or 'mitokine,' helping cells communicate stress responses. It is naturally produced by the body and has been linked to neuroprotection, metabolic regulation, and cellular vitality, often showing increased levels following physical exercise.

P21 is a protein that acts as a key regulator of the cell cycle, primarily functioning to halt cell division in response to DNA damage or cellular stress. It is central to the process of cellular senescence, where it helps determine cell fate by either facilitating repair or marking damaged cells for clearance by the immune system.

Klotho is a protein primarily produced in the kidneys and brain that acts as an anti-aging factor. It regulates mineral metabolism, inhibits key inflammatory and pro-aging signaling pathways, and helps protect tissues from damage and senescence.